Brad delivers a seminar sponsored by the DF/HCC Connect:Science seminar series and the Leukemia & Lymphoma Society. In the midst of the Covid-19 pandemic, researchers continue to engage.
You can read the study in Nature
Brad was interviewed for the ACS Theory lab podcast last week! “Cancer has classically been thought of as a genetic disease, but…”
Volker Hovestadt, Kyle S. Smith, Laure Bihannic, Mariella G. Filbin together led this study of medulloblastoma cellular heterogeneity. Congratulations to the team! Medulloblastoma is a malignant childhood cerebellar tumor type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their divergent biology and … Continued
Yotam Drier (Bernstein lab) and Paloma Cejas (Shivdasani lab at DFCI) describe how enhancer signatures in non-functional PNET tumors can be used to stratify subtypes and predict patient outcomes. Read the paper in Nature Medicine. This was a great collaboration between the Bernstein lab at MGH, the Shivdasani lab at DFCI, several teams of clinicians … Continued
Congratulations Fadi on a successful defense! You can also checkout Fadi’s Nature Biotech paper! Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens. Najm FJ, Strand C, Donovan KF, Hegde M, Sanson KR, Vaimberg EW, Sullender ME, Hartenian E, Kalani Z, Fusi N, Listgarten J, Younger ST, Bernstein BE, Root DE, Doench JG. Nat Biotechnol. 2018
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. van Galen P, Hovestadt V, Wadsworth Ii MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE. Cell. 2019 Mar … Continued
Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution. Shema E, Bernstein BE, Buenrostro JD. Nat Genet. 2019 Jan Recent advances in single-cell and single-molecule epigenomic technologies now enable the study of genome regulation and dynamics at unprecedented resolution. In this Perspective, we highlight some of these transformative technologies and discuss how they … Continued
“The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin et al. used a single-cell sequencing approach to study the oncogenic programs, genetics, and cellular hierarchies of H3K27M-glioma. Tumors were mainly composed of cells resembling oligodendrocyte precursor cells, whereas … Continued
Congratulations to Dan on the successful defense of his PhD thesis!